Dr Karen Rowland Yeo is Senior Vice-President, Client & Regulatory Strategy at Certara UK Limited’s Simcyp Division. Prior to this, she was the Head of PBPK Consultancy Services at Simcyp where she led a team of scientists engaged in Consultancy projects relating to the application of physiologically based pharmacokinetic (PBPK) modeling in the drug development process. This involved putting a framework in place for developing PBPK models used for both internal decision-making and regulatory submissions. Her work ranged across most therapeutic areas and included the development of models used for dosing of special populations and assessment of drug-drug interactions. Prior to joining Simcyp Ltd in 2002, Karen held a 5-year lectureship in the Department of Clinical Pharmacology & Therapeutics at the University of Sheffield. Karen has been the author/co-author of more than 100 peer reviewed articles and is frequently called as an invited speaker and session organiser/moderator at international meetings in the field.